CLINICAL TIER

Cellular Detection (IS3)

Early-Stage Pathology & Tissue Topology

The Challenge of Stain Variability

In histological imaging, preparation inconsistencies—such as variation in stain intensity and tissue thickness—often create "noise" that baffles standard statistical AI. These statistical models are prone to bias, frequently failing to generalize across different protocols. This is the foundational bottleneck in large-scale clinical diagnostics.

The IS3 Clinical Engine addresses this through our proprietary Topological Chaos Indexing. This technology—protected by U.S. Patent Application No. 63/940,736 and 63/983,021—isolates the mathematical signature of tissue growth via the ISED Pathology Kernel [CLASSIFIED].

IP_Notice: The specific integral used for Betti Number Fingerprinting is withheld to preserve clinical detection superiority. The power of IS3 lies in the non-disclosed persistence thresholds that identify Stage-1 markers without false positives.

Topological Persistence Analysis

                                MODE: ACTIVE

                                TARGET: LOCKED

CLINICAL_INTEGRITY_FEED

                                [IS3] Scanning slide batch 14A...

                                [ISED] Betti Number persistence stable.

                                [AUDIT] Clinical Parity Verified.

Industrial Metric	Performance Standard
Detection Rate	98.2% (Stage-1 Recall)
Scanning Res.	Sub-Micron (0.4μm)
Stain Tolerance	Zero-Stain Dependency
Diagnostic Tier	Deterministic (Medical-Grade)

Technical Verification | Eulerian Magnification

Standard raw optical feeds (top) often contain "invisible" signals buried in pixel noise—such as the subtle color flush of a pulse or micro-tremors in tissue.

IS3 (A20) utilizes Eulerian Video Magnification (EVM) to isolate and amplify these biological frequencies (0.8Hz - 2.0Hz). Providing non-contact vital sign monitoring and tissue perfusion analysis with medical-grade accuracy.

TEST_ID: BIO_EVM_V2 TARGET: PULSE_AMP_50X

Clinical Value & Applications

IS3 removes the human-eye bias from early-stage screening by operating on the structural geometry of tissue — not pixel patterns that shift with stain protocols:

Oncology Screening — 98.2% Stage-1 recall with zero stain dependency, enabling large-scale population screening without protocol standardization
Drug Development — Topological tracking of tissue response across treatment cohorts, providing deterministic efficacy metrics
Veterinary Pathology — Cross-species tissue analysis without retraining, since topology is species-invariant

Failure Boundary: IS3 requires minimum 0.4μm scanning resolution. Below this threshold, topological features become indistinguishable from noise.